Derecho a la salud y calidad asistencial en contextos de crisis sanitaria: la trombosis venosa profunda en pacientes hospitalizados con COVID-19 en Brasil
DOI:
https://doi.org/10.54899/dcs.v23i88.4947Palavras-chave:
COVID-19, Trombosis Venosa Profunda, Derecho a la Salud, Seguridad del Paciente, Gestión HospitalariaResumo
Introducción: La pandemia de COVID-19 evidenció desafíos en la seguridad del paciente hospitalizado. Entre las complicaciones asociadas a la infección por SARS-CoV-2, la trombosis venosa profunda (TVP) destaca por su relación con el estado protrombótico de la enfermedad y por su carácter potencialmente prevenible. Desde una perspectiva jurídico-sanitaria, su ocurrencia también plantea cuestiones sobre la calidad asistencial y el cumplimiento del derecho a la salud. Objetivos: Evaluar la incidencia de TVP en pacientes hospitalizados con COVID-19 y analizar su asociación con características clínicas y desenlaces hospitalarios. Metodología: Estudio observacional analítico retrospectivo basado en la revisión de registros clínicos de pacientes adultos hospitalizados entre marzo de 2020 y octubre de 2024 en un hospital terciario de Sergipe, Brasil. De 6.281 pacientes elegibles, 5.831 fueron incluidos. Se analizaron variables sociodemográficas, comorbilidades, ingreso en UCI, ventilación mecánica, uso de dispositivos invasivos, duración de hospitalización y desenlaces. Se aplicaron análisis estadísticos descriptivos y comparativos (p < 0,05). Resultados: Se identificaron 69 casos de TVP (1,18%) y una incidencia global de tromboembolismo venoso de 2,45%. Los pacientes con TVP presentaron mayor edad, mayor prevalencia de comorbilidades y mayor gravedad clínica, con más ingresos en UCI, ventilación mecánica y uso de dispositivos invasivos. También mostraron mayor duración de hospitalización (22 vs 8 días) y mayor mortalidad (37,68% vs 11,09%; p<0,001). Discusión: La TVP se asoció con mayor gravedad clínica, mayor utilización de recursos hospitalarios y peor evolución en pacientes con COVID-19, lo que refuerza la importancia de estrategias de estratificación de riesgo y tromboprofilaxis durante la hospitalización. Conclusión: La TVP constituye una complicación prevenible de alto impacto clínico y sanitario. Desde un enfoque interdisciplinario entre medicina y derecho, su prevención y manejo oportuno son esenciales para garantizar la seguridad del paciente y el derecho a la salud en contextos de crisis sanitarias.
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Referências
AL-ANI, Fatimah; CHEHADE, Samer; LAZO-LANGNER, Alejandro. Thrombosis risk associated with COVID-19 infection. A scoping review. Thrombosis Research, v. 192, p. 152–160, 1 ago. 2020.
ALLEGRA, Alessandro et al. Coagulopathy and thromboembolic events in patients with SARS-CoV-2 infection: pathogenesis and management strategies. Annals of Hematology, v. 99, n. 9, p. 1953–1965, 1 set. 2020.
BONAVENTURA, Aldo et al. Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19. Nature Reviews Immunology, v. 21, n. 5, p. 319–329, 1 maio 2021.
BOONYAWAT, Kochawan et al. Incidence of thromboembolism in patients with COVID-19: a systematic review and meta-analysis. Thrombosis Journal, v. 18, n. 1, 1 dez. 2020.
CHANG, Heepeel et al. Deep vein thrombosis in hospitalized patients with coronavirus disease 2019. Journal of Vascular Surgery: Venous and Lymphatic Disorders, v. 9, n. 3, p. 597–604, 1 maio 2021.
CHEN, Shujing et al. DVT incidence and risk factors in critically ill patients with COVID-19. Journal of Thrombosis and Thrombolysis, v. 51, n. 1, p. 33–39, 1 jan. 2021.
CHI, Gerald et al. Venous thromboembolism among hospitalized patients with COVID-19 undergoing thromboprophylaxis: A systematic review and meta-analysis. Journal of Clinical Medicine, v. 9, n. 8, p. 1–17, 1 ago. 2020.
ERBEN, Young et al. Deep vein thrombosis and pulmonary embolism among hospitalized coronavirus disease 2019–positive patients predicted for higher mortality and prolonged intensive care unit and hospital stays in a multisite healthcare system. Journal of Vascular Surgery: Venous and Lymphatic Disorders, v. 9, n. 6, p. 1361- 1370.e1, 1 nov. 2021.
GIANNIS, Dimitrios; ZIOGAS, Ioannis A.; GIANNI, Panagiota. Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past. Journal of Clinical Virology, v. 127, 1 jun. 2020.
HELMS, Julie et al. High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study. Intensive Care Medicine, v. 46, n. 6, p. 1089–1098, 1 jun. 2020.
IBA, Toshiaki; CONNORS, Jean Marie; LEVY, Jerrold H. The coagulopathy, endotheliopathy, and vasculitis of COVID-19. Inflammation Research, v. 69, n. 12, p. 1181–1189, 1 dez. 2020.
JAYARANGAIAH, Apoorva et al. COVID-19-Associated Coagulopathy: An Exacerbated Immunothrombosis Response. Clinical and Applied Thrombosis/Hemostasis, v. 26, 2020.
JIMÉNEZ, David et al. Incidence of VTE and Bleeding Among Hospitalized Patients With Coronavirus Disease 2019: A Systematic Review and Meta-analysis. Chest, v. 159, n. 3, p. 1182–1196, 1 mar. 2021.
KATSOULARIS, Ioannis et al. Risks of deep vein thrombosis, pulmonary embolism, and bleeding after covid-19: nationwide self-controlled cases series and matched cohort study. BMJ (Clinical research ed.), v. 377, p. e069590, 6 abr. 2022.
KLOK, F. A. et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thrombosis Research, v. 191, p. 145–147, 1 jul. 2020a.
KLOK, F. A. et al. Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis. Thrombosis Research, v. 191, p. 148–150, 1 jul. 2020b.
KOLLIAS, Anastasios et al. Venous thromboembolism in COVID-19: A systematic review and meta-analysis. Vascular Medicine (United Kingdom), v. 26, n. 4, p. 415–425, 1 ago. 2021.
LIU, Yandong et al. A systematic review and meta-analysis of incidence, prognosis, and laboratory indicators of venous thromboembolism in hospitalized patients with coronavirus disease 2019. Journal of Vascular Surgery: Venous and Lymphatic Disorders, v. 9, n. 5, p. 1099- 1111.e6, 1 set. 2021.
LODIGIANI, Corrado et al. Venous and arterial thromboembolic complications in COVID-19 patients admitted to an academic hospital in Milan, Italy. Thrombosis Research, v. 191, p. 9–14, 1 jul. 2020.
LONGCHAMP, Gregoire et al. Proximal deep vein thrombosis and pulmonary embolism in COVID-19 patients: a systematic review and meta-analysis. Thrombosis Journal, v. 19, n. 1, 1 dez. 2021.
MACKMAN, Nigel et al. Coagulation Abnormalities and Thrombosis in Patients Infected With SARS-CoV-2 and Other Pandemic Viruses. Arteriosclerosis, Thrombosis, and Vascular Biology, v. 40, n. 9, p. 2033–2044, 1 set. 2020.
MANSORY, Eman M.; SRIGUNAPALAN, Suthan; LAZO-LANGNER, Alejandro. Venous Thromboembolism in Hospitalized Critical and Noncritical COVID-19 Patients: A Systematic Review and Meta-analysis. TH Open, v. 05, n. 03, p. e286–e294, jul. 2021.
MARINI, Corrado P. et al. Incidence and effects of deep vein thrombosis on the outcome of patients with coronavirus disease 2019 infection. Journal of Vascular Surgery: Venous and Lymphatic Disorders, v. 10, n. 4, p. 803–810, 1 jul. 2022.
MIDDELDORP, Saskia et al. Incidence of venous thromboembolism in hospitalized patients with COVID-19. Journal of Thrombosis and Haemostasis, v. 18, n. 8, p. 1995–2002, 1 ago. 2020.
PONS, Stéphanie et al. The vascular endothelium: The cornerstone of organ dysfunction in severe SARS-CoV-2 infection. Critical Care, v. 24, n. 1, 16 jun. 2020.
PORFIDIA, Angelo et al. Venous thromboembolism in patients with COVID-19: Systematic review and meta-analysis. Thrombosis Research, v. 196, p. 67–74, 1 dez. 2020.
SEMERARO, Nicola; COLUCCI, Mario. The prothrombotic state associated with SARS-CoV-2 infection: Pathophysiological aspects. Mediterranean Journal of Hematology and Infectious Diseases, v. 13, n. 1, 1 jun. 2021.
SUH, Young Joo et al. Pulmonary Embolism and Deep Vein Thrombosis in COVID-19: A Systematic Review and Meta-Analysis. Radiology, v. 298, n. 2, p. E70–E80, 1 fev. 2021.
TAN, Boun Kim et al. Arterial and venous thromboembolism in COVID-19: A study-level meta-analysis. Thorax, v. 76, n. 10, p. 970–979, 1 out. 2021.
VINAYAGAM, Sathishkumar; SATTU, Kamaraj. SARS-CoV-2 and coagulation disorders in different organs. Life Sciences, v. 260, 1 nov. 2020.
ZHANG, Chi et al. Incidence of Venous Thromboembolism in Hospitalized Coronavirus Disease 2019 Patients: A Systematic Review and Meta-Analysis. Frontiers in cardiovascular medicine, v. 7, 6 ago. 2020a.
ZHANG, Chi et al. Incidence of Venous Thromboembolism in Hospitalized Coronavirus Disease 2019 Patients: A Systematic Review and Meta-Analysis. Frontiers in Cardiovascular Medicine, v. 7, 6 ago. 2020b.
ZHANG, Li et al. Deep Vein Thrombosis in Hospitalized Patients with COVID-19 in Wuhan, China: Prevalence, Risk Factors, and Outcome. Circulation, v. 142, n. 2, p. 114–128, 14 jul. 2020c.
ZHANG, Vicky et al. Prevalence and Association of Deep Vein Thrombosis on Clinical Outcomes among COVID-19 Patients. Infectious Diseases in Clinical Practice, v. 32, n. 6, 1 nov. 2024.
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