INCORPORAÇÃO DE NANOPARTÍCULAS DE COBRE EM SISTEMAS ADESIVOS: REVISÃO INTEGRATIVA DA LITERATURA
DOI:
https://doi.org/10.54899/dcs.v22i85.3336Resumo
A estabilidade da interface resina-dentina continua sendo um desafio na Odontologia Restauradora, devido à ação de enzimas endógenas e à infiltração microbiana, que comprometem a durabilidade da adesão. A incorporação de nanopartículas de cobre (CuNp) em sistemas adesivos tem sido investigada como uma estratégia bioativa promissora para minimizar esses efeitos. Esta revisão integrativa de literatura teve como objetivo reunir e analisar criticamente a evidência científica disponível sobre os efeitos das CuNp no desempenho clínico de adesivos odontológicos, com ênfase em suas propriedades antimicrobianas, físico-químicas e mecânicas. A busca foi realizada em agosto de 2025 nas bases PubMed, LILACS, Web of Science, Science Direct e Scopus, utilizando os descritores “Copper” e “Dentin-bonding Agents”, combinados pelo operador booleano “AND”. Foram incluídos artigos publicados entre 2015 e 2025, em inglês, português ou espanhol. Após a triagem de 1477 estudos, 8 contemplaram os critérios de elegibilidade. Os dados de trabalhos laboratoriais indicam que as CuNp, em concentrações entre 0,1% e 0,5%, promovem efeito antimicrobiano, reduzem a nanoinfiltração e aumentam a estabilidade da camada híbrida, sem comprometer suas propriedades mecânicas. No entanto, os ensaios clínicos disponíveis não demonstram benefícios relevantes em parâmetros como retenção, adaptação e pigmentação marginal.
Downloads
Referências
AMIN, F. et al. Degradation and stabilization of resin-dentine interfaces in polymeric dental adhesives: an updated review. Coatings, v. 12, n. 8, p. 1094, 2022.
BEDRAN-RUSSO, A. K. et al. Dentin biomodification: strategies, renewable resources and clinical applications. Dental Materials, v. 30, p. 62–76, 2014.
BOURGI, R. et al. A literature review of adhesive systems in dentistry: key components and their clinical applications. Applied Sciences, v. 14, n. 18, p. 8111, 2024.
BRESCHI, L. et al. Dentin bonding systems: from dentin collagen structure to bond preservation and clinical applications. Dental Materials, v. 34, n. 1, p. 78–96, 2018.
BRESCHI, L. et al. The evolution of adhesive dentistry: from etch-and-rinse to universal bonding systems. Dental Materials, S0109-5641(24)003397, 2024.
CADENARO, M. et al. Degree of conversion and permeability of dental adhesives. European Journal of Oral Sciences, v. 113, n. 6, p. 525–530, 2005.
FRASSETTO, A. et al. Mechanisms of degradation of the hybrid layer in adhesive dentistry and therapeutic agents to improve bond durability—A literature review. Dental Materials, v. 32, n. 2, p. e41–e53, 2016.
GUTIÉRREZ, M. F. et al. Mechanical and microbiological properties and drug release modeling of an etch-and-rinse adhesive containing copper nanoparticles. Dental Materials, v. 33, n. 3, p. 309–320, 2017a.
GUTIÉRREZ, M. F. et al. The role of copper nanoparticles in an etch-and-rinse adhesive on antimicrobial activity, mechanical properties and the durability of resin-dentine interfaces. Journal of Dentistry, v. 61, p. 12–20, 2017b.
GUTIÉRREZ, M. F. et al. Biological, mechanical and adhesive properties of universal adhesives containing zinc and copper nanoparticles. Journal of Dentistry, v. 82, p. 45–55, 2019.
HANNAS, A. R. et al. The role of matrix metalloproteinases in the oral environment. Acta Odontologica Scandinavica, v. 65, n. 1, p. 1-13, 2007.
HANZEN, T. A. et al. A universal dental adhesive containing copper nanoparticles stabilizes the hybrid layer in eroded dentin after 1 year. International Journal of Adhesion & Adhesives, v. 113, p. 103041, 2022.
LOPEZ, K. M.; GREENAWAY, F. T. Identification of the copper-binding ligands of lysyl oxidase. Journal of Neural Transmission, v. 118, p. 1101–1109, 2011.
MATOS, T. P. et al. 18-month clinical evaluation of a copper-containing universal adhesive in non-carious cervical lesions: a double-blind, randomized controlled trial. Journal of Dentistry, v. 90, p. 103219, 2019.
MATOS, T. P. et al. 48-month clinical evaluation of a copper-containing universal adhesive in non-carious cervical lesions: a double-blind randomized clinical trial. Dental Materials, v. 39, p. 820–830, 2023.
MAZZONI, A. et al. Effects of etch-and-rinse and self-etch adhesives on dentin MMP-2 and MMP-9. Journal of Dental Research, v. 92, n. 1, p. 82–86, 2013.
ÑAÚPARI-VILLASANTE, R. et al. Four-year effects of copper-nanoparticles on durability of resin-dentin interfaces. International Journal of Adhesion & Adhesives, v. 119, p. 103253, 2022.
ÑAÚPARI-VILLASANTE, R. et al. Six-year clinical evaluation of a copper-containing universal adhesive in non-carious cervical lesions: a split-mouth double-blind randomized clinical trial. Journal of Dentistry, v. 153, p. 105532, 2025.
OBEID, A. T. et al. Surface mineral deposition and mechanical properties of one-step bonding agent with copper-modified niobium nanoparticles – An in vitro study. International Journal of Adhesion & Adhesives, v. 133, p. 103764, 2024.
PASHLEY, D. H. et al. State of the art etch-and-rinse adhesives. Dental Materials, v. 27, n. 1, p. 1–16, 2011.
ROSIN, M. et al. Hybrid layer quality of universal adhesives: a systematic literature review. Research, Society and Development, v. 12, n. 5, p. e8612541489, 2023.
RUPARELIA, J. P. et al. Strain specificity in antimicrobial activity of silver and copper nanoparticles. Acta Biomaterialia, v. 4, n. 3, p. 707-716, 2008.
SCHMIDT, M. G. et al. Copper continuously limits the concentration of bacteria resident on bed rails within the intensive care unit. Infection Control and Hospital Epidemiology, v. 34, n. 5, p. 530-533, 2013.
SOUZA, A. P.; GERLACH, R. F.; LINE, S. R. Inhibition of human gingival gelatinases (MMP-2 and MMP-9) by metal salts. Dental Materials, v. 16, n. 2, p. 103–108, 2000.
TAY, F. R. et al. Single-step adhesives are permeable membranes. Journal of Dentistry, v. 30, n. 7–8, p. 371–382, 2002.
TJÄDERHANE, L. et al. Dentin basic structure and composition — An overview. Endodontic Topics, v. 20, n. 1, p. 3–29, 2009.
USMAN, M. S. et al. Synthesis, characterization, and antimicrobial properties of copper nanoparticles. International Journal of Nanomedicine, v. 8, p. 4467-4479, 2013.
VALLET, S. D.; RICARD-BLUM, S. Lysyl oxidases: from enzyme activity to extracellular matrix cross-links. Essays in Biochemistry, v. 63, p. 349–364, 2019.
VAN MEERBEEK, B. et al. From Buonocore’s pioneering acid-etch technique to self-adhering restoratives. A status perspective of rapidly advancing dental adhesive technology. The Journal of Adhesive Dentistry, v. 22, n. 1, p. 7–34, 2020.
VIDAL, O. et al. A universal adhesive containing copper nanoparticles improves the stability of hybrid layer in a cariogenic oral environment: an in situ study. Journal of the Mechanical Behavior of Biomedical Materials, v. 126, p. 105017, 2022.
WANG, Y. et al. Cuprous oxide nanoparticles selectively induce apoptosis of tumor cells. International Journal of Nanomedicine, v. 7, p. 2641-2652, 2012.
YOON, K. Y. et al. Susceptibility constants of Escherichia coli and Bacillus subtilis to silver and copper nanoparticles. The Science of the Total Environment, v. 373, n. 2-3, p. 572-575, 2007.
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Copyright (c) 2025 Revista DCS
Este trabalho está licenciado sob uma licença Creative Commons Attribution-NonCommercial 4.0 International License.
